IGHE and anaphylaxis: Despite the pathological role of IgE being implicated by the function of IgE, adverse reactions to omalizumab have also been reported due to the formation of immune complexes between the monoclonal antibody and its target IgE antibody, leading to the manifestation of skin inflammation and anaphylaxis through an IgG receptor-dependent mechanism (i.e., Fcγ) (135).