We thus analysed data from 240 cognitively unimpaired (CU) and 485 cognitively impaired (CI) participants from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort to investigate if SNPs within the FNDC5 gene are associated with changes in FDG-PET, cognition and AD biomarkers. This evidence concerns the gene FNDC5 and Alzheimer disease.