FNDC5 and early-onset autosomal dominant Alzheimer disease: We thus analysed data from 240 cognitively unimpaired (CU) and 485 cognitively impaired (CI) participants from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort to investigate if SNPs within the FNDC5 gene are associated with changes in FDG-PET, cognition and AD biomarkers.