In contrast, Chen et al. (2015) reported that low expression of RACK1 may enhance the autocrine IL8 through miRNA-302c and contribute to an invasive or metastatic phenotype of gastric cancer, indicating the relationship between decreased RACK1 and poor prognosis in patients with GC; and Zhang et al. (2019) found that RACK1 down-regulation might be responsible for the occurrence of PC in its early stage by activating the NF-κB pathway (Hu et al., 2019). This evidence concerns the gene RACK1 and pachyonychia congenita.