Notably, RACK1 may promote the migration and invasion of malignant tumors by mediating the epithelial-mesenchymal transition in LC, the PI3K/Akt pathway in PC, and the AMPK/YAP pathway in CRC (Kong et al., 2020; Qu et al., 2017; Sun et al., 2021). This evidence concerns the gene AKT1 and colorectal carcinoma.