A total of seven hub genes were included in multivariate COX regression analysis (Fig. 3A), and a prognostic model of bladder tumor was established according to the regression coefficients: Riskscore = (0.014 *expression of ACLY) +(0.007 * expression of CNP) +(0.010 * expression of NKIRAS2) +(0.024 * expression of P3H4) +(0.002 * expression of PDIA6) +(−0.004* expression of VPS25) +(−0.010* expression of XPO1). The gene discussed is ACLY; the disease is urinary bladder neoplasm.