It plays a crucial role in the regulation of glucose homeostasis, insulin secretion, and the pathogenesis of diabetes mellitus (Price et al., 1996; Kawaguchi et al., 2006; Song et al., 2013; Uruno et al., 2013; Al-Khalili et al., 2014; Yang et al., 2016; Balaji et al., 2018; Yamada et al., 2018). Here, INS is linked to diabetes mellitus.