These results were validated by a similar study that looked at 5mC expression in four models of RP, the rd1 and rd2 mouse models, which have mutations in the Pde6b and Prph2 genes, respectively, and the P23H and S334ter rat models, which harbor mutations in the Rho gene (Farinelli et al., 2014). This evidence concerns the gene PDE6B and retinitis pigmentosa 1.