PARP1 and achromatopsia: More broadly, PARP overactivity was consistently elevated compared to wildtype controls in ten models of IRD, namely the P23H and S334ter rat models of autosomal dominant RP, rd1, rd2, rd10, Cngb1−/− and Rho−/− mice models of autosomal recessive RP, the Rpe65−/− model of Leber’s congenital amaurosis and the Pde6ccpfl1 and Cnga3−/− models of achromatopsia (Arango-Gonzalez et al., 2014).