These inflammatory factors, such as interleukin (IL)-1β and tumor necrosis factor (TNF)-α, further aggravate IDD by exacerbating the inflammatory response, inhibiting IVD cell proliferation and differentiation, accelerating cellular senescence and apoptosis, and promoting ECM degradation (Rogers et al., 2017; Song et al., 2017; Wang et al., 2020). The gene discussed is TNF; the disease is intervertebral disk degenerative disorder.