Notably, in the context of cancer, ERK5 has emerged as a critical survival mechanism for tumor cells, helping them withstand the stress induced by anticancer drugs, thereby promoting cancer progression (Kato et al., 1998; Mehta et al., 2003; Montero et al., 2009; Ramsay et al., 2011; Stecca and Rovida, 2019; Monti et al., 2022; Abe et al., 2023). The gene discussed is MAPK7; the disease is cancer.