Notably, ERK5 depletion in cancer cells hinders cancer growth, proliferation, and the expression of proteins involved in angiogenesis (e.g., CD31) and extracellular matrix integrity, thereby influencing cancer biology (Sato et al., 2005; Hoang et al., 2017; Paudel et al., 2021). The gene discussed is MAPK7; the disease is cancer.