As shown previously (Hartz et al., 2022), this value is much higher (56 P450s and AdR) when comparing PD patients with unknown origin of the disease (IPD) and HC, where only CYP46A1 as well as Adx and POR were demonstrated to display SNPs with OR values >5 compared to HC. The gene discussed is CYP46A1; the disease is Parkinson disease.