However, the over-expression of GM-CSF will over-mobilize HSCs in the temporary non-proliferation phase, which will make them enter the cell proliferation cycle prematurely, resulting in the excessive production and activation of granulocytes and macrophages, ultimately reducing the body’s hematopoietic function, and even inducing a variety of hematological diseases (Dhagat et al., 2018). The gene discussed is CSF2; the disease is hematologic disorder.