In addition, the integrated analysis of metabolomics and transcriptomics was conducted to preliminarily explore the protective effect of MDBD on radiation-induced leukopenia in mice through multi-pathways, mainly including steroid biosynthesis and IL-17 signaling pathway, among which the key genes were Jun, Cxcl2 and Egr1. Here, IL17A is linked to Decreased total leukocyte count.