EGFR and Alzheimer disease: Several genes [e.g., epidermal growth factor receptor (EGFR) and amyloid precursor protein (APP)] are associated with both cancer and AD, and we and others have recently found that anti-cancer drugs can penetrate the blood-brain barrier (BBB) and modulate AD pathology (Ryu and McLarnon, 2008; Cramer et al., 2012).