It contains sesame lignans (including sesamol), which have an inhibitory effect on cholesterol 24S-hydroxylase (CYP46A1), which is a brain-specific cytochrome P450 and plays a significant role in the cholesterol catabolism in the brain tissues, preventing cerebral ischemia in the middle cerebral arteries and inhibiting the cerebral apoptotic pathway (Du et al., 2022). Here, CYP46A1 is linked to Cerebral ischemia.