CYP46A1 and brain ischemia: It contains sesame lignans (including sesamol), which have an inhibitory effect on cholesterol 24S-hydroxylase (CYP46A1), which is a brain-specific cytochrome P450 and plays a significant role in the cholesterol catabolism in the brain tissues, preventing cerebral ischemia in the middle cerebral arteries and inhibiting the cerebral apoptotic pathway (Du et al., 2022).