We further found that PD-L1 in cells and exosomes was significantly increased when PD-L1 was overexpressed (p < 0.01, p < 0.05), while JPYZXZ treatment could reverse these phenomena (p < 0.05, p < 0.05), however, PD-L1 overexpression attenuated these inhibitory effect (Figures 4I–L), which supported that exosomal PD-L1 is potential target of JPYZXZ in GC. This evidence concerns the gene CD274 and gastric cancer.