ARG1 and ischemic stroke: In animal models of cerebral ischemia, the STAT6/arginase 1 (STAT6/Arg1) pathway contributes to phagocytosis of dead/dying cells by microglia and macrophages, and upregulating STAT6/Arg1 signaling reduces brain infarction and facilitates long-term functional recovery at 3 and 7 days following ischemic stroke in mice (Cai et al., 2019).