Lack of microgliosis confirms that LRRK2 mice do not model the overt phase of PD since samples from sporadic PD patients show evidence of microglial activation [29–31] and both sporadic PD and, to a lower degree, LRRK2 PD patients present with a proinflammatory blood markers profile [77,78]. Here, LRRK2 is linked to Parkinson disease.