Treatment with acetate and butyrate inhibited the development of hypertension and normalized Firmicutes and Bacteroides (F/B) ratios. In addition, Th17 cell/Treg cell balance in mesenteric lymph nodes was restored, endotoxemia was normalized, and mRNA expression levels of tight junction protein occlusive protein and ZO-1 in colon were increased. Here, TJP1 is linked to hypertensive disorder.