FAR2 and hypertensive disorder: Prebiotic treatment to prevent HF-induced hypertension was found to be associated with reduced plasma acetate levels and reduced renal mRNA expression, whereas probiotic treatment increased plasma propionate levels and restored the HF-induced reduction in FAR2 (Fatty Acyl-CoA Reductase 2) expression. Maternal HF diet has long-term programming effects on GM in adult offspring. Maternal GM-targeted therapies may be influencing the progression of hypertension by reprogramming and, in turn, influencing the progression of hypertension.