Furthermore, dysregulation of key enzymes involved in GPL synthesis and degradation, such as phosphocholine cytidylyltransferase (CCT) and phospholipase A2 has been associated with insulin resistance and T2DM (Sakai et al., 2014; Kuefner, 2021; Siddiqui et al., 2022). Here, IL31RA is linked to type 2 diabetes mellitus.