TLE3 and Familial prostate cancer: AR, HOXB13, and TLE3 were identified as the top three master regulators in prostate cancer (Fig. 2B), which is also in line with previous findings (Heinlein and Chang 2004, Palit et al. 2019, Jamroze et al. 2021, Darst et al. 2022, Lu et al. 2022).