Our collocation analyses revealed 19 master regulators in LGG and 18 master regulators in GBM, of which 11 (NEUROG2, OLIG2, RARA, SOX2, SOX3, SOX8, SOX21, CHD7, MYOG, MYF5, FOXO1-PAX3) are shared (Fig. 2E and F). The gene discussed is SOX21; the disease is glioblastoma.