The immune response in COVID-19, which may result in ARDS, involves the unbalanced secretion of various inflammatory cytokines and chemokines, including TNF-α, IL-1β, IFN-γ, IL-6, IL-10, IL–1RA, IP–10, MCP–1, and IL-8 (CXCL8). This evidence concerns the gene IL6 and COVID-19.