SIRPA and neoplasm: The gCM shell overexpresses the SIRPα variant at the gene level with a 50,000-fold enhanced affinity for CD47, effectively blocking the CD47-SIRPα signaling pathway, while the MN nucleus promotes M2 to M1 repolarization, restores macrophage phagocytosis of tumor cells and triggers antitumor T cells immunity (146).