HA-AuNR/M-M2pep NP, which is a gold nanorod modified with hyaluronic acid (HA), can cleave the MMP2-sensitive peptide on the surface of tumor cells, leading to the release of M2pep, the selective consumption of M2-TAM, the recruitment of TILs, the activation of T cells, and the secretion of anti-tumor cytokines (like IFN-γ and TNF-α). The gene discussed is TNF; the disease is neoplasm.