Specific mechanisms include: a) the release of cell-associated antigens when tumor cells undergo death; b) the capture and presentation of antigens by dendritic cells (DCs); c) the initiation and activation of T cells; d) the recruitment of T cells to the tumor site; e) the infiltration of T cells into the tumor tissue; f) the recognition of corresponding tumor cells by T cells; and g) the killing of tumor cells by T cells via the secretion of granzyme, perforin, and other effectors (1). Here, PRF1 is linked to neoplasm.