FCGR3A and infection: Epistatic interaction of FcγRIIIa polymorphisms and IgG1 allotypes has been observed in HSV-1 infection such that, as a result of enhanced ADCC, the high affinity FcγRIIIa-158V/V genotype was only associated with asymptomatic infection in individuals homozygous for the G1m3 IgG1 allotype (434), typically linked to reduced IgG1 responses against viral infections.