CD1D and graft versus host disease: At 9- and 13-week post-BMT, the cell numbers, frequencies of iNKT cells (TCRβ+PBS57:CD1d-tetramer (CD1d-tet)+), and iNKT/T ratios in the thymus, spleen, and liver were significantly lower in mice with GvHD than those with BM only (Figures 1A; S1D), agreeing well with the previous results of impaired iNKT cell reconstitution in allo-HSCT patients with GvHD (2, 16–19).