PSMB10 and inborn error of immunity: Genetic screening using a primary immunodeficiency targeted gene panel was inconclusive, and WES was performed at the age of 1 year and 5 months, which revealed two novel PSMB10 variants (c.40_42del and p.Phe14del, which are also present in patients 2 and 3) and a third novel PSMB10 splice site variant (c.710 + 1G>C) (Figure 1A).