IRF3 and Epstein-Barr virus infection: Study have reported that new KSHV and HSV-1 infections and latent KSHV and EBV infections can induce the interaction of the H2B-IFI16-BRCA1 complex with intracellular cGAS and STING, leading to the phosphorylation of TBK1 and IRF3, nuclear translocation of IRF3, and production of IFN-γ (76).