Increasing evidence suggests that the cGAS-STING signaling pathway plays a key pathogenic role in autoimmune diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Aicardi-Goutières syndrome (AGS), and STING-associated vasculopathy with onset in infancy (SAVI). This evidence concerns the gene STING1 and vascular disorder.