Furthermore, some of these compounds are thieno [2,3-d]imidazole derivatives that can induce tumor regression in mice without inducing weight loss as noval STING agonists (132), and some are oral STING agonists that can induce long-lasting antitumor immunity when combined with other drugs to overcome immunotherapy resistance synergistically (133). The gene discussed is STING1; the disease is neoplasm.