However, global CRISPRi and CRISPRn screens for host factors affecting HCMV infections (conducted with HCMV-Merlin in HFFs) neither showed significant advantages nor disadvantages regarding HCMV infection associated with a loss of TNFRSF1B coding capacity (see supplementary data set of (92)). Here, TNFRSF1B is linked to cytomegalovirus infection.