It is still unclear how the identified mutations affect ZEB2 function and how mutant ZEB2 contributes to B-All pathogenesis, however these mutations do appear to be associated exclusively with the “B-other” ALL subtype, which lacks common B-All associated fusion proteins such as BCR-ABL1, ETV-RUNX1 and MLL-fusions (163). This evidence concerns the gene ZEB2 and acute lymphoblastic leukemia.