In addition, Insulin-like growth factor-1/2(IGF1/2), chemokine (C-X-C motif) ligand 12(CXCL12), and beta-hydroxybutyrate produced by CAFs can induce autophagy of cancer cells after RT, and promote recovery of irradiated cancer cells and tumor regeneration after RT. The gene discussed is CXCL12; the disease is cancer.