Previous studies have also found that downregulation of KLF3 expression inhibits the progression of lung cancer by inhibiting the JAK2/STAT3 and PI3K/AKT signaling pathways (49); KLF3 silencing promotes lung cancer EMT and enhances lung cancer metastasis through the STAT3 signaling pathway (14); KLF3 activates WNT through WNT1/β-catenin signaling pathway to promote the growth and metastasis of gastric cancer (50); of course, the specific mechanism of KLF3 regulating tumors is not comprehensive enough, and more in-depth mechanism exploration is needed in the future. The gene discussed is STAT3; the disease is lung carcinoma.