KLF3 and cancer: Furthermore, through analysis of paired cancer and normal tissues in the TCGA database, we found that KLF3 mRNA was upregulated in CHOL (p < 0.01) and PAAD (p < 0.001), but significantly downregulated in BRCA (p < 0.001), COAD (p < 0.001), KICH (p < 0.001), THCA (p < 0.001), and UCEC (p < 0.001) compared with paired normal tissues (Figure 1B).