For example, studies have shown that KLF3 becomes a key regulator of metastasis by controlling the expression of STAT3 in lung cancer, and silencing KLF3 promote lung cancer EMT and enhances lung cancer metastasis (14); Another study showed that miR-365a-3p targets KLF3 to inhibit colorectal cancer cell migration, invasion and chemotherapy resistance (15). This evidence concerns the gene STAT3 and lung cancer.