From a pan-cancer perspective, it was found that: immune-related genes VEGFA, C10orf54, CD276, EDNRB, ARG1, HMGB1, ENTPD1, BTN3A1, TLR4, BTN3A2 were significantly positively correlated with KLF3 expression, whereas VEGFB expression was negatively correlated with KLF3 expression. This evidence concerns the gene CD276 and cancer.