IGHE and Splenomegaly: AIL mapping detected the new locus Lmr34 on chromosome 17 with a peak of linkage D17Mit139 (52.9 Mbp) that controls IgE level in the serum, skin lesion size, splenomegaly, and hepatomegaly (Figure 1B), which is probably distinct from Lmr1 that spans from 10 to 86 Mbp and is linked to H2 (35 Mbp) (24).