Skin lesions (main and int. Lmr18); splenomegaly; hepatomegaly; parasite load in the lymph nodes (main, int. Lmr27 in males); parasite load in the liver; eosinophil infiltration into the lymph nodes int. Lmr26; IL-4 and IgE in the serum. Here, IGHE is linked to Splenomegaly.