The two patients who died as a consequence of CRS grade 5-carHLH presented the highest ferritin (218,725 and 180,395 ug/l) and bilirubin levels (7 mg/dl for both patients), as well as tumor burden, but CRP did not show statistically significant differences, as it is shown in Supporting Information 5. This evidence concerns the gene CRP and congenital rubella syndrome.