iv) The exclusion of CD4 T cells expressing CD161 (48) and/or Vα24Jα18 during the single cell RNA library preparation might have impacted the frequency of pTh17 cells in the inflamed intestinal sites of CD patients, which could explain why only patient #3 has presented cytotoxic pTh17 cells in their inflamed tissue. The gene discussed is KLRB1; the disease is Cowden disease.