Regions near known pTh17-related genes, such as IL23R, and regions near other genes, such as ATG16L1, ANKRD55 and THADA, are also highly enriched in both pTh17 cells and inflamed biopsies relative to other CD4 T cell subpopulations and non-inflamed biopsies, respectively, and where IBD-risk SNPs fall within (Figure S6). This evidence concerns the gene IL23R and inflammatory bowel disease.