Using the chromatin profiles of CD4 T cells cultured under Th1, Th2, Treg-like, rTh17 and pTh17 conditions, the chromatin accessibility changes revealed a higher predominance of pTh17 cells in inflamed intestinal sites of IBD patients, even though the cells used for profiling the chromatin accessibility of the T cell subsets were not presorted and were composed of an admixture of polarized and non-polarized CD4 T cells, which might have masked the identification of some known lineage-specific DNA recognition motif families. This evidence concerns the gene CD4 and inflammatory bowel disease.