UFL1 and Infertility: Furthermore, OS results in ER stress, and Ufm1-specific ligase 1 (UFL1) alleviates cisplatin-induced apoptosis in ovarian GCs by attenuating ER stress, thereby relieving POI to some extent (254).The key to POI is the reduction in the quantity and quality of oocytes, which results in symptoms such as hot flashes, excessive sweating, vaginal dryness, and even causes serious consequences such as infertility.