TSC2 and Infertility: (80) found that knockdown of the TSC1/TSC2 gene was able to activate mTOR of phosphatase and tensin homology deleted on chromosome 10 (PTEN)/tuberous sclerosis complex 1 (TSC1)/tuberous sclerosis complex 2 (TSC2) in germ cells leading to primordial follicle recruitment, POI and infertility (81).