Numerous studies have previously reported the regulatory effects of irisin on the NF-κB pathway, for example, irisin reduces the inflammatory response by decreasing the level of NF-kB in serum, thus treating rats with acute pelvic inflammatory disease (APID) (48), irisin exerts anti-inflammatory and anti-apoptotic effects by blocking NF-κB-signal transmission, and plays a protective role against liver injury (49), kidney injury (50) and metabolic diseases (51). Here, NFKB1 is linked to metabolic disease.