It has been shown that treatment of a SW1353 chondrosarcoma cell line with irisin resulted in inhibition of the Wnt/β-catenin and NF-κB signaling pathways, and irisin exerted a protective effect on SW1353 cells by reducing the expression level of MMP-13 and increasing the expression level of collagen II (Col-II), which demonstrates that irisin may contribute to the treatment of OA (52). This evidence concerns the gene FNDC5 and chondrosarcoma.