Hyperglycemia, AGEs, mitochondrial oxidative stress and ultrafiltration cytokines act on renal tubular cells and trigger multiple cellular pathways such as PKC-α, -β, and -δ, NF-κB, P38 and ERK1/2 pathways, further exacerbating renal tubular cell hypertrophy, apoptosis, and accumulation of tubulointerstitial inflammatory factors (3). Here, NFKB1 is linked to Hyperglycemia.