Given that P1-HNF4α has been shown to repress the P2 promoter either directly or indirectly (80, 83, 104), could it be simply that the tumor suppressive P1-HNF4α must be decreased in order for the hepatocytes to proliferate and that once its expression is reduced, P2-HNF4α expression is coincidentally increased? Here, HNF4A is linked to neoplasm.