HNF4A and cancer: Furthermore, while mutations in the human HNF4A gene and/or its target genes have been associated with several diseases, including hemophilia (1), inflammatory bowel disease (IBD) (2) and various cancers, including hepatocellular, colorectal, renal, and gastric carcinomas (3–5), this review will focus on its role in carbohydrate and lipid metabolism in the liver.