In humans, HNF4α‐AS1(NR_109949.1) is a 648 nucleotide, antisense RNA located between the P1 and P2 promoters which makes it ideal for playing a role in the regulation of promoter switching; tellingly, it has also been implicated as a biomarker in hepatocellular carcinoma (HCC) and Crohn’s disease (102, 103). Here, HNF4A is linked to hepatocellular carcinoma.