DUOX2 is important for thyroid hormones production and in innate immunity (Maruo et al., 2016), Mfsd2b important in S1P transport activity (Kobayashi et al., 2018) essential for various cellular functions (Spiegel and Milstien, 2011; Cyster and Schwab, 2012), ITGA5 involved in different inflammation and immune response functions such as PI3K–Akt signaling pathway, bacterial invasion of epithelial cells, phagosome and human papillomavirus infection (Wang et al., 2021). The gene discussed is DUOX2; the disease is human papilloma virus infection.