KL and osteoporosis: The PPI network analysis revealed 10 key genes associated with osteoporosis: FGF8, KL, CCL3, FGF4, IL9, FGF9, BMP7, IL17RA, IL12RB2, CD40LG. Expression level of IL17RA was found to be significantly high in osteoporotic patients upon external dataset validation, suggesting that IL17RA may be an effective biomarker for osteoporosis.