The PPI network analysis revealed 10 key genes associated with osteoporosis: FGF8, KL, CCL3, FGF4, IL9, FGF9, BMP7, IL17RA, IL12RB2, CD40LG. Expression level of IL17RA was found to be significantly high in osteoporotic patients upon external dataset validation, suggesting that IL17RA may be an effective biomarker for osteoporosis. This evidence concerns the gene CD40LG and osteoporosis.