CHDH and male infertility: Different studies have found that CHDH is closely associated with the development of several diseases, including malignancies (Chen et al., 2022; Wei et al., 2022; Zhang et al., 2022), psychiatric disorders (Chang et al., 2017; Truong et al., 2022), male infertility (Johnson et al., 2012; Lazaros et al., 2012), tooth agenesis (Mostowska et al., 2011) and hyperhomocysteinemia (Kumar et al., 2009).