Zhang et al. screened differentially expressed genes (DEGs) associated with clinical traits by DEG analysis and weighted gene co-expression network analysis (WGCNA), finally identified six prognostic metabolism-related genes including CHDH, and constructed a CHDH prognostic model, showing that low expression of CHDH was significantly associated with poorer overall survival (OS) in ccRCC patients. Here, CHDH is linked to nonpapillary renal cell carcinoma.