Van et al. validated that induction of necroptosis by intra-tumoral delivery of mRNA encoding MLKL to colon cancer models inhibited tumor formation and distant metastasis, mechanistically through rapid triggering of tumor antigen-specific CD4 and CD8 T-cell responses, which required Batf3-dependent cDC1 and DC migration (Van Hoecke et al., 2018). Here, CD4 is linked to malignant colon neoplasm.