Changes in neurogenesis are followed by decreased expression of Notch1, NICD, and Hes5 in the context of the pathogenesis of PD, suggesting that accumulation of–synuclein may impede nasopharyngeal carcinoma (NPC) survival by impairing the Notch signaling system (Zhang et al., 2020). Here, HES5 is linked to nasopharyngeal carcinoma.