CHAC1 and gastric cancer: Tanshinone IIA (Tan IIA) upregulated the expression of the ferroptosis markers Ptgs2 and Chac1 in gastric cancer cells and downregulated the expression of SCL7A11 by mediating the expression of P53, which in turn caused a decrease in intracellular GSH and cysteine levels and an increase in ROS levels, inhibiting the proliferation of gastric cancer cells [72].