Furthermore, the article “Ferroptosis as a p53-mediated Activity during Tumour Suppression” [21] was written by Jiang, L, in 2015 and was published in Nature. This work is of great importance because it reveals that the SLC7A11 gene is a target of P53 and that P53 regulates cystine metabolism, modulates the ROS response and inhibits tumour growth via ferroptosis, which further expanded the understanding of the classical antitumour factor p53. This evidence concerns the gene TP53 and neoplasm.