GPX4 and acute kidney injury: This work was the first to utilize inducible Gpx4 (−/−) mice for use in relevant experiments, providing the most direct evidence at the genetic level that Gpx4 knockdown leads to cell death with the characteristics of ferroptosis and further elucidating the important role of the glutathione/Gpx4 axis in preventing lipid peroxidation-driven acute renal failure.