Quercetin has been considered an ideal therapeutic agent in the treatment of PD due to its ability to improve the OS of periodontal ligament cells as well as prevent alveolar bone resorption (Wei et al., 2021), and some studies have demonstrated in vitro, its ability to dampen the production of inflammatory mediators such as IL-1 β, IL-6, IL-8, and TNF- α (He et al., 2020). Here, TNF is linked to Parkinson disease.