Finally, we considered the role of plant-derived melatonin for its anti-inflammatory properties; however, both experimental and clinical studies, yield contradictory results; while some report a significant reduction in IL-6 TNF- levels in patients with type 2 diabetes and periodontitis, other studies found no significant effects of its efficacy (Bazyar et al., 2019; Konečná et al., 2021). This evidence concerns the gene TNF and periodontitis.