Adding to these co-existing conditions are rare genetic disorders and disorders of known etiology, like Down Syndrome (Rasmussen et al., 2001; Bradbury et al., 2021), SHANK3 deletion syndrome (Phelan et al., 1993; Torres et al., 2016a; Schaffler et al., 2019), Fragile X (Kaufmann et al., 2017), various forms of Cerebral Palsy (Pahlman et al., 2020, 2021; Gecz and Berry, 2021), just to name a few. The gene discussed is SHANK3; the disease is Down syndrome.