ODC1 and human African trypanosomiasis: Interest in the kinetoplastid proteasome (Hua et al., 1995) arose in the 1990 s as a result of the discovery and validation of ornithine decarboxylase (ODC) as the drug target for eflornithine (D, L, α-difluoromethylornithine) (Bacchi et al., 1980) for the treatment of Human African Trypanosomiasis (Van Nieuwenhove et al., 1985).