CXCL8 and rheumatoid arthritis: Detailed analysis of genes enriched in RA-related pathways revealed that the expression of CCL3, CXCL8, CCL3L1, and CCL2 was upregulated in RA monocytes, while the expression of some human leukocyte antigen (HLA) genes was downregulated (Figure 3(g), Supplementary 13).