In a genomic sequencing study, Kawamura et al. examined genetic variants in 3 CPVT-related genes: RYR2, calsequestrin 2 (CASQ2), and inward-rectifier K+ channel 2 (KCNJ2) in 50 unrelated Japanese CPVT-diagnosed probands as well as designated RYR2 genotyped and non-genotyped groups (76). The gene discussed is RYR2; the disease is catecholaminergic polymorphic ventricular tachycardia.