CLEC4D and myocardial ischemia: At the same time, during myocardial ischemia-re-perfusion injury, endogenous ligands released by tissue damage activate Toll-like receptors, NOD-like receptors, C-type lectin receptors, and RIG-1-like receptors (23), thereby initiating natural immune responses (24), and then transcriptionally regulate the production of pro-inflammatory mediators, including cytokines, chemokines, and adhesion molecules, leading to tissue inflammation, thereby aggravating myocardial ischemia-re-perfusion injury.