IL18 and Venous thrombosis: Colchicine inhibits the activation of NLRP3 inflammasome and thus reduces the production of interleukin (IL)-1β and IL-18 mediated by it (51, 52) since neutrophil enzymes activate IL-1β and IL-18 extracellularly, and colchicine also inhibits the reduction of the release of neutrophil granulocyte enzymes associated with thrombosis, which is one of its potential anti-inflammatory mechanisms (53, 54).