TUBB3 and Alzheimer disease: TUBB3 R262C syndrome [784C > T]: Over 100 individuals from 20 pedigrees have been reported; 14 AD inheritance, 6 do novoTischfield et al., 2010; Ceylan et al., 2017; Stark et al., 2017; Dillon et al., 2018; Jia et al., 2022).