In addition, in mouse embryos, Martínez et al. recently used CRISPR-Cas9 technology to insert a stop codon into exon 3 of Aspm, which partially reduced ASPM levels at the centrosome and caused mild microcephaly, with decreased brain weight and volume at P30 (González-Martínez et al., 2021). The gene discussed is ASPM; the disease is microcephaly.